The character in Steve Canyon introduced in 1953, was Lt Peter Pipper was based on JFK

Miss Mizzou was based on Marilyn Monroe

https://www.airandspaceforces.com/PDF/MagazineArchive/Documents/2007/July%202007/0707cartoon.pdf

https://www.airandspaceforces.com/PDF/MagazineArchive/Documents/2013/April%202013/0413caniff.pdf

https://www.airandspaceforces.com/PDF/MagazineArchive/Magazine%20Documents/1996/February%201996/0296fifty.pdf